Successful treatment of rhinocerebral mucormycosis by a combination of aggressive surgical debridement and the use of systemic liposomal amphotericin B and local therapy with nebulized amphotericin--a case report.

Abstract

A case of mucormycosis involving the nose and paranasal sinuses in a 55-year-old man with recently diagnosed acute promyelocytic leukaemia is reported. It was successfully treated with a combination of aggressive surgical debridement and systemic amphotericin B. In addition, local nebulized amphotericin B was used as an adjunct to therapy. We believe this is only the second documented use of nebulized amphotericin in the management of sinonasal mucormycosis. The need for a high index of suspicion and early aggressive management is emphasized.

• Authors: P Raj, E J Vella, R C Bickerton
• Journal: The Journal of laryngology and otology (J Laryngol Otol) Vol. 112 Issue 4 Pg. 367-70 (Apr 1998) ISSN: 0022-2151 [Print] England
• PMID: 9659500 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents
• Liposomes
• Amphotericin B

Topics

• Amphotericin B (administration & dosage)
• Antifungal Agents (administration & dosage)
• Combined Modality Therapy
• Humans
• Liposomes
• Male
• Middle Aged
• Mucormycosis (diagnosis, drug therapy, surgery)
• Nebulizers and Vaporizers
• Nose Diseases (diagnosis, drug therapy, surgery)
• Paranasal Sinus Diseases (diagnosis, drug therapy, surgery)
• Tomography, X-Ray Computed