[Efficacy and safety of dotarizine vs. cinnarizine in the symptomatic treatment of acute balance disorders (common vertigo)].

Abstract	One hundred and ten adult patients suffering from peripheral vertigo were treated in a multifactorial double-blind randomized clinical trial with dotarizine (50 mg b.i.d.) or cinnarizine (75 mg b.i.d.). There was a 60 days clinical follow-up. Results showed that dotarizine was significantly active against the vertigo attacks and its associated symptoms (mainly neurovegetative). The global superiority of dotarizine was confirmed by statistically significant differences between treatments in the improvement of the severity of vertigo, hearing loss in audiometries, global relief of symptoms, disability produced by crises and global assessment by the investigators themselves. No clinically significant unwanted effects were seen in either group on blood pressure, heart rate or analytical parameters. No serious adverse effects to dotarizine were reported. This study confirms the value of dotarizine in the treatment of peripheral vertigo.
Authors	E Perelló, E Esteller, A Colls, C Magriñá, H Massegur, J Lluansí, J F Casamitjana, X Lao, F Roca-Ribas, N Miró, J Prades, E Herrero, O Molá, J Torres, M Márquez, J A Ortiz
Journal	Anales otorrinolaringologicos ibero-americanos (An Otorrinolaringol Ibero Am) Vol. 25 Issue 3 Pg. 291-310 ( 1998) ISSN: 0303-8874 [Print] Spain
Vernacular Title	Eficacia y seguridad de dotarizina frente a cinarizina en el tratamiento sintomático de los trastornos agudos del equilibrio (vértigo común).
PMID	9658668 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References	Benzhydryl Compounds Calcium Channel Blockers Histamine H1 Antagonists Piperazines Serotonin Antagonists Cinnarizine dotarizine
Topics	Acute Disease Adolescent Adult Aged Aged, 80 and over Benzhydryl Compounds (therapeutic use) Calcium Channel Blockers (therapeutic use) Cinnarizine (therapeutic use) Double-Blind Method Female Histamine H1 Antagonists (therapeutic use) Humans Male Middle Aged Piperazines (therapeutic use) Serotonin Antagonists (therapeutic use) Treatment Outcome Vertigo (drug therapy)

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