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Cyclophosphamide, adriamycin, 5-fluorouracil and high-dose toremifene for patients with advanced/recurrent breast cancer. The Japan Toremifene Cooperative Study Group.

AbstractBACKGROUND:
Multi-combination chemotherapy consisting of anthracyclines has been effective but has not invariably prolonged the survival period in advanced/recurrent breast cancer. The possibility has been discussed that chemoendocrine therapy combined with endocrine agents is more effective.
METHODS:
In order to evaluate the toxicity and efficacy of a new endocrine therapy for advanced/recurrent breast cancer, we ran a pilot study during the period from July 1994 to July 1996.
RESULTS:
Twenty-two patients with advanced/recurrent breast cancer were treated with chemoendocrine therapy consisting of cyclophosphamide (100 mg/body) p.o. daily for 14 days, with adriamycin (40 mg/m2) i.v. and 5-fluorouracil (500 mg/body) i.v. on day 1 (repeated every 3 weeks for 9 weeks) (CAF therapy), and high-dose toremifene (120 mg/body) p.o. daily. Of 20 evaluable patients, two showed complete response (10%), eight partial response (40%), six no change (30%) and four progressive disease (20%). The overall response rate was 50%, and the median duration of response was 69.5 days (28-133+ days). The major toxicities were drug-induced alopecia, gastrointestinal toxicity and hematological toxicity, but these were clinically well tolerated. No serious cardiac, liver or renal symptom was seen.
CONCLUSIONS:
Based on these results, we consider the addition of high-dose toremifene to the CAF therapy to be useful in the treatment of advanced and recurrent breast cancer.
AuthorsT Tominaga, Y Nomura, J Uchino, K Hirata, M Kimura, M Yoshida, H Aoyama, H Kinoshita, H Koyama, Y Monden, S Takashima, M Ogawa
JournalJapanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 28 Issue 4 Pg. 250-4 (Apr 1998) ISSN: 0368-2811 [Print] England
PMID9657010 (Publication Type: Journal Article)
Chemical References
  • Estrogen Antagonists
  • Toremifene
  • Doxorubicin
  • Cyclophosphamide
  • Fluorouracil
Topics
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Breast Neoplasms (drug therapy)
  • Cyclophosphamide (administration & dosage)
  • Doxorubicin (administration & dosage)
  • Drug Administration Schedule
  • Estrogen Antagonists (administration & dosage)
  • Female
  • Fluorouracil (administration & dosage)
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local (drug therapy)
  • Toremifene (administration & dosage)

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