Abstract |
Several studies have found weak associations between certain human leukocyte antigen (HLA) alleles and sarcoidosis, but none have been conclusive. Glutamic acid at position 69 in HLA-DPB1 has been reported to be strongly associated with chronic beryllium disease. The immunopathologic and clinical similarities between chronic beryllium disease (CBD) and sarcoidosis suggest that similar immune-response genes may be involved in susceptibility in both diseases. We analyzed the DNA sequence of HLA-DPB1 exon 2, which contains the hypervariable regions involved in binding antigens, in blood samples from African-American sarcoidosis patients and healthy controls. Results indicate that Val36 (odds ratio [OR] = 2.30) and Asp55 (OR = 2.03) are associated with increased risk for sarcoidosis, but no association with Glu69 was found. These results suggest that although HLA-DPB1 Glu69 is not associated with sarcoidosis, other alleles may make some contribution to susceptibility to sarcoidosis in African-Americans.
|
Authors | M J Maliarik, K M Chen, M L Major, R G Sheffer, J Popovich Jr, B A Rybicki, M C Iannuzzi |
Journal | American journal of respiratory and critical care medicine
(Am J Respir Crit Care Med)
Vol. 158
Issue 1
Pg. 111-4
(Jul 1998)
ISSN: 1073-449X [Print] United States |
PMID | 9655715
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- HLA-DP Antigens
- Immunoglobulin Variable Region
|
Topics |
- Adult
- Aged
- Alleles
- Black People
(genetics)
- Female
- HLA-DP Antigens
(genetics)
- Humans
- Immunoglobulin Variable Region
- Male
- Middle Aged
- Phenotype
- Polymorphism, Genetic
- Sarcoidosis, Pulmonary
(ethnology, genetics)
- Sequence Analysis, DNA
|