Resolution of xanthomas in Alagille syndrome after liver transplantation.

Abstract

Alagille syndrome (arteriohepatic dysplasia) is a genetic disorder with autosomal dominant transmission which has been localized to chromosome 20p. Cutaneous manifestations include jaundice, pruritus, and widespread xanthomata. We report a child with severe Alagille syndrome in whom orthotopic liver transplantation caused rapid resolution of disfiguring xanthomas.

• Authors: D A Buckley, E M Higgins, A W du Vivier
• Journal: Pediatric dermatology (Pediatr Dermatol) 1998 May-Jun Vol. 15 Issue 3 Pg. 199-202 ISSN: 0736-8046 [Print] United States
• PMID: 9655315 (Publication Type: Case Reports, Journal Article)

Topics

• Alagille Syndrome (complications, surgery)
• Child
• Follow-Up Studies
• Hand Dermatoses (etiology, physiopathology)
• Humans
• Liver Transplantation (adverse effects)
• Male
• Xanthomatosis (etiology, physiopathology)