Abstract | PURPOSE: MATERIALS AND METHODS: Cellular distribution of Apo-D, PSA and AR in 30 stage A/B prostate cancers and in non-malignant glandular tissue contained in the same sections was detected immunohistochemically, and staining was evaluated by computerized video image analysis. RESULTS: Staining for Apo-D (percentage positive cellular area) was significantly increased in tumor cells of early stage prostate cancers compared with non-malignant glandular tissue. PSA and AR were present at high levels in both early stage prostate tumors and non-malignant prostate. CONCLUSIONS: Malignant transformation in the prostate is associated with increased cellular levels of Apo-D.
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Authors | S X Zhang, J M Bentel, C Ricciardelli, D J Horsfall, D E Haagensen, V R Marshall, W D Tilley |
Journal | The Journal of urology
(J Urol)
Vol. 159
Issue 2
Pg. 548-54
(Feb 1998)
ISSN: 0022-5347 [Print] United States |
PMID | 9649289
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins
- Apolipoproteins D
- Receptors, Androgen
- Prostate-Specific Antigen
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Topics |
- Apolipoproteins
(analysis)
- Apolipoproteins D
- Humans
- Immunohistochemistry
- Male
- Neoplasm Staging
- Prostate-Specific Antigen
(analysis)
- Prostatic Neoplasms
(chemistry, pathology)
- Receptors, Androgen
(analysis)
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