Alpha-fetoprotein producing pulmonary blastoma in a patient with systemic sclerosis: pathogenetic analysis.

Abstract

We describe a rare case of pulmonary blastoma complicated with systemic sclerosis. The serum alpha-fetoprotein level was elevated at presentation and the biopsied tumour stained positively against anti-alpha-fetoprotein antibody. The alpha-fetoprotein produced autonomously by tumour cells was of yolk-sac origin. Although the pathogenesis of pulmonary blastoma has not been clarified, we suggest that this pulmonary blastoma is a type of yolk-sac tumour.

• Authors: I Kasuga, D Miyamoto, Y Ichinose, W Chimangul, K Minemura, K Utsumi, M Yonemaru, H Serizawa, Y Ebihara, K Toyama
• Journal: The European respiratory journal (Eur Respir J) Vol. 11 Issue 5 Pg. 1185-7 (May 1998) ISSN: 0903-1936 [Print] England
• PMID: 9648976 (Publication Type: Case Reports, Journal Article)

Chemical References

• alpha-Fetoproteins

Topics

• Female
• Humans
• Lung (diagnostic imaging, pathology)
• Lung Neoplasms (complications, diagnosis, metabolism)
• Middle Aged
• Pulmonary Blastoma (complications, diagnosis, metabolism)
• Radiography, Thoracic
• Scleroderma, Systemic (complications)
• Tomography, X-Ray Computed
• alpha-Fetoproteins (biosynthesis)