Abstract | OBJECTIVES: METHODS: A total of 120 cirrhotic patients with acute upper gastrointestinal bleeding were enrolled. Sixty patients received ciprofloxacin 500 mg twice daily given orally or through nasogastric tube immediately after upper gastrointestinal endoscopic examination; drug administration continued for 7 days. The remaining 60 patients, who received placebo, served as controls. RESULTS: The incidence of proven bacterial infection in the ciprofloxacin-treated group was significantly lower than that of placebo group (10% vs 45%, p < 0.001). The incidences of bacteremia, spontaneous bacterial peritonitis, and urinary tract infection in the ciprofloxacin-treated group were significantly lower than those in the placebo group (0% vs 23%, 3.3% vs 13%, and 5% vs 18%, respectively; p < 0.05, respectively). Multivariate logistic regression analysis showed that a lack of prophylactic treatment with ciprofloxacin and severity of cirrhosis were the independent significant predictors for cirrhotic patients with acute gastrointestinal bleeding with infection. CONCLUSIONS:
|
Authors | W J Hsieh, H C Lin, S J Hwang, M C Hou, F Y Lee, F Y Chang, S D Lee |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 93
Issue 6
Pg. 962-6
(Jun 1998)
ISSN: 0002-9270 [Print] United States |
PMID | 9647029
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Infective Agents
- Ciprofloxacin
|
Topics |
- Acute Disease
- Administration, Oral
- Anti-Infective Agents
(administration & dosage, therapeutic use)
- Bacterial Infections
(prevention & control)
- Ciprofloxacin
(administration & dosage, therapeutic use)
- Female
- Gastrointestinal Hemorrhage
(complications)
- Humans
- Liver Cirrhosis
(complications)
- Liver Cirrhosis, Alcoholic
(complications)
- Male
- Middle Aged
- Regression Analysis
|