Primary manifestation of Hodgkin's disease in the central nervous system.

Abstract

A 62-year-old woman presented with loss of memory and a mild hemiparesis. Neuroradiology demonstrated a left frontoparietal tumour. Biopsy specimens of this lesion revealed intracerebral Hodgkin's lymphoma, a diagnosis supported by immunohistochemical reactions of the tumour cells for the CD30 antigen. Additional cell cycle studies revealed a high proliferative activity of the tumour cells in association with absence of apoptosis. There was no evidence that overexpression of bcl-2 or Epstein-Barr virus infection was involved in the pathogenesis of this neoplasm. Lymphomas in the lung were detected 3 months later. Following neurosurgical excision, radiotherapy, and chemotherapy, the patient had no evidence of Hodgkin's disease after 13 months of follow-up.

• Authors: M Deckert-Schlüter, J Marek, M Setlík, J Marková, E Pakos, R Fischer, O D Wiestler
• Journal: Virchows Archiv : an international journal of pathology (Virchows Arch) Vol. 432 Issue 5 Pg. 477-81 (May 1998) ISSN: 0945-6317 [Print] Germany
• PMID: 9645450 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ki-1 Antigen
• Proto-Oncogene Proteins c-bcl-2

Topics

• Apoptosis
• Brain Neoplasms (diagnosis, metabolism)
• Diagnosis, Differential
• Female
• Hodgkin Disease (diagnosis, metabolism)
• Humans
• Immunohistochemistry
• Ki-1 Antigen (metabolism)
• Lymphoma, B-Cell (metabolism, pathology)
• Magnetic Resonance Imaging
• Mediastinal Neoplasms (diagnostic imaging, pathology)
• Middle Aged
• Proto-Oncogene Proteins c-bcl-2 (metabolism)
• Radiography
• Reed-Sternberg Cells (pathology)