Abstract | AIM: Characterization of Sjogren's disease (SD) with onset at early age basing on the comparison of two patient groups--with the disease onset at the age under 30 and over 50. MATERIALS AND METHODS: Clinical, ophthalmological and stomatological examinations were performed in 31 SD patients who developed the disease at the age under 30 (group 1) and over 50 (group 2). RESULTS: In group 1 the disease started with parotitis in 42.8% of cases, dysfunction of secreting epithelial glands was rare, functional activity of exocrine glands was normal, dysproteinemia (high total protein levels, hypergammaglobulinemia, hypoalbuminemia) and immunological defects (high levels of circulating immune complexes, rheumatoid factor, antinuclear factor) were more pronounced. At retrospective analysis not only a decline of functional activity of the salivary and lacrimal glands but also appearance of systemic symptoms were registered. CONCLUSION:
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Authors | V G Gracheva, V I Vasil'ev, M V Simonova, T N Safonova, S M Ivanova, N G Guseva |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 70
Issue 5
Pg. 55-8
( 1998)
ISSN: 0040-3660 [Print] Russia (Federation) |
Vernacular Title | Kliniko-laboratornaia kharakteristika bol'nykh bolezn'iu Shegrena s nachalom zabolevaniia v molodom vozraste. |
PMID | 9644745
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Antibodies, Antinuclear
- Antigen-Antibody Complex
- Serum Albumin
- gamma-Globulins
- Rheumatoid Factor
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Topics |
- Adolescent
- Adult
- Age Factors
- Aged
- Antibodies, Antinuclear
(blood)
- Antigen-Antibody Complex
(blood)
- Conjunctiva
(pathology)
- Female
- Humans
- Lacrimal Apparatus
(pathology)
- Male
- Middle Aged
- Mouth Mucosa
(pathology)
- Parotid Gland
(pathology)
- Retrospective Studies
- Rheumatoid Factor
(blood)
- Serum Albumin
(metabolism)
- Sjogren's Syndrome
(blood, diagnosis, etiology)
- gamma-Globulins
(metabolism)
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