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A new taxane diterpenoid from Taxus mairei.

Abstract
A new 11(15-->1)-abeotaxane diterpene, taxumairol K (1), has been isolated from the ethanolic extract of the roots of Formosan Taxus mairei (Lemee & Levl.) S. Y. Hu. The structure of 1 was determined as 9alpha-(benzoyloxy)-2alpha,4alpha- diacetoxy-5beta ,20-epoxy-1beta, 7beta,10beta,13alpha-tetrahydroxy-11(15-->1)-abeota xane on the basis of spectral analysis. Taxumairol K (1) exhibited mild cytotoxicity against HeLa tumor cells.
AuthorsY C Shen, C Y Chen, Y H Kuo
JournalJournal of natural products (J Nat Prod) Vol. 61 Issue 6 Pg. 838-40 (Jun 26 1998) ISSN: 0163-3864 [Print] United States
PMID9644081 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Taxoids
  • taxumairol K
  • Paclitaxel
Topics
  • Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
  • China
  • Drug Screening Assays, Antitumor
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Paclitaxel (analogs & derivatives, isolation & purification, pharmacology)
  • Plants, Medicinal (chemistry)
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Taxoids
  • Tumor Cells, Cultured

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