Abstract |
A new 11(15-->1)-abeotaxane diterpene, taxumairol K (1), has been isolated from the ethanolic extract of the roots of Formosan Taxus mairei (Lemee & Levl.) S. Y. Hu. The structure of 1 was determined as 9alpha-(benzoyloxy)-2alpha,4alpha- diacetoxy-5beta ,20-epoxy-1beta, 7beta,10beta,13alpha-tetrahydroxy-11(15-->1)-abeota xane on the basis of spectral analysis. Taxumairol K (1) exhibited mild cytotoxicity against HeLa tumor cells.
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Authors | Y C Shen, C Y Chen, Y H Kuo |
Journal | Journal of natural products
(J Nat Prod)
Vol. 61
Issue 6
Pg. 838-40
(Jun 26 1998)
ISSN: 0163-3864 [Print] United States |
PMID | 9644081
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Taxoids
- taxumairol K
- Paclitaxel
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Topics |
- Antineoplastic Agents, Phytogenic
(isolation & purification, pharmacology)
- China
- Drug Screening Assays, Antitumor
- Humans
- Magnetic Resonance Spectroscopy
- Mass Spectrometry
- Paclitaxel
(analogs & derivatives, isolation & purification, pharmacology)
- Plants, Medicinal
(chemistry)
- Spectrophotometry, Infrared
- Spectrophotometry, Ultraviolet
- Taxoids
- Tumor Cells, Cultured
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