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Dramatic resolution of pleural effusion in children with chronic myelomonocytic leukemia following short-course high-dose methylprednisolone.

Abstract
High-dose methylprednisolone (HDMP) which can induce--differentiation and -apoptosis of myeloid leukemic cells has been shown to be very effective in the treatment of extramedullary infiltration (EMI) of children with acute myeloblastic leukemia (AML). In the present study 2 children with chronic myelomonocytic leukemia (CMML) who had pleural effusions were given a single daily dose of oral methylprednisolone (20 mg/kg or 30 mg/kg). In addition to dramatic improvement of respiratory symptoms, pleural effusions disappeared in four days in both patients possibly due to apoptotic cell death induced by HDMP treatment. Further studies are needed to determine whether high-dose corticosteroids are also effective on the resolution of pleural effusions associated with other malignant disease.
AuthorsG Hiçsönmez, M Cetin, B Tunç, A M Tuncer, F Gümrük, I Yenicesu
JournalLeukemia & lymphoma (Leuk Lymphoma) Vol. 29 Issue 5-6 Pg. 617-23 (May 1998) ISSN: 1042-8194 [Print] United States
PMID9643576 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Glucocorticoids
  • Methylprednisolone
Topics
  • Adolescent
  • Apoptosis (drug effects)
  • Child
  • Dyspnea (etiology)
  • Fatal Outcome
  • Female
  • Glucocorticoids (administration & dosage, pharmacology, therapeutic use)
  • Humans
  • Leukemia, Myelomonocytic, Chronic (complications)
  • Male
  • Methylprednisolone (administration & dosage, pharmacology, therapeutic use)
  • Neoplastic Stem Cells (drug effects, pathology)
  • Pleural Effusion, Malignant (drug therapy, etiology, pathology)

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