HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Growth promotion by homocysteine but not by homocysteic acid: a role for excessive growth in homocystinuria or proliferation in hyperhomocysteinemia?

Abstract
Excessive growth of long bones in patients with homocystinuria is still unexplained and previous work incriminating homocysteic acid could not be confirmed by others. In vitro studies from our laboratory showed that homocysteine stimulated growth in a clonogenic assay. This observation made us study plasma cyclin dependent kinase (CDK), homocyst(e)ine and homocysteic acid in 10 patients with homocystinuria and 20 controls. In addition, homocysteine and homocysteic acid were tested in a clonogenic assay to correlate the growth promoting activity with CDK. Plasma CDK (protein) correlated strongly with homocysteine (r=0.84) but not with homocysteic acid. Supernatants of the clonogenic assay samples showed up to three times higher CDK levels in the presence of homocyst(e)ine but not homocysteic acid. In vitro data and the strong correlation between homocysteine and CDK suggest a role for homocysteine stimulating CDK, the starter of mitosis, with subsequent stimulation of growth.
AuthorsM Fritzer-Szekeres, H J Blom, G H Boers, T Szekeres, B Lubec
JournalBiochimica et biophysica acta (Biochim Biophys Acta) Vol. 1407 Issue 1 Pg. 1-6 (Jul 01 1998) ISSN: 0006-3002 [Print] Netherlands
PMID9639661 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Homocysteine
  • homocysteic acid
  • homocysteine thiolactone
  • CDC2 Protein Kinase
  • Cystathionine beta-Synthase
Topics
  • Adolescent
  • Adult
  • Aged
  • CDC2 Protein Kinase (blood)
  • Cell Division (drug effects)
  • Cystathionine beta-Synthase (deficiency)
  • Female
  • Homocysteine (analogs & derivatives, analysis, blood, pharmacology)
  • Homocystinuria (metabolism, therapy)
  • Humans
  • Male
  • Middle Aged

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: