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Neuroleptic-induced dementia documented in four adults with mental retardation.

Abstract
This is the first report to my knowledge of neuroleptic-induced dementia in adults with mental retardation. Four adults showed full recovery after having significant cognitive deterioration that persisted until the offending medication was withdrawn. The ages at onset of dementia were 37, 37, 39, and 55 years; the duration of dementia ranged from .5 to 2.5 years. Three adults had Down syndrome and one had mental retardation due to an unknown cause. The neuroleptic-induced dementia occurred while the individuals were on a low dose of either loxapine, thioridazine, haloperidol, or pimozide.
AuthorsA Gedye
JournalMental retardation (Ment Retard) Vol. 36 Issue 3 Pg. 182-6 (Jun 1998) ISSN: 0047-6765 [Print] United States
PMID9638038 (Publication Type: Case Reports, Journal Article)
Topics
  • Adult
  • Dementia (chemically induced, diagnosis)
  • Dose-Response Relationship, Drug
  • Down Syndrome (drug therapy)
  • Female
  • Follow-Up Studies
  • Humans
  • Intellectual Disability (drug therapy)
  • Male
  • Middle Aged

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