[Treatment of keloid with intralesional bleomycin].

Abstract

INTRODUCTION:

Treatment of keloids is often disappointing and sometime quite difficult to manage. In addition to unpleasant esthetic effects, treatment may also produce functional impairment due to pruritus and contraction of the scar tissue.

PATIENTS AND METHODS:

We proposed a new treatment scheme using intralesional infiltrations of bleomycin.

RESULTS:

We treated 31 keloids and 5 hypertrophic scars with 3 to 5 infiltrations with a 1-month period. Total regression was obtained in 25 keloids and hypertrophic scars. Important regression was obtained in 6 keloids (86% good results). Treatment was effective in all cases within the first 2 infiltrations evidenced by a reduction in the volume of the keloid and clear reduction of functional impairment in most patients.

CONCLUSION:

Effective well-tolerated treatment without pain was achieved with infiltration suggesting that this treatment should be used as first line therapy for keloids.

• Authors: I Bodokh, P Brun
• Journal: Annales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 123 Issue 12 Pg. 791-4 ( 1996) ISSN: 0151-9638 [Print] France
• Vernacular Title: Traitement des chéloïdes par infiltrations de bléomycine.
• PMID: 9636763 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Bleomycin

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antibiotics, Antineoplastic (administration & dosage, therapeutic use)
• Bleomycin (administration & dosage, therapeutic use)
• Female
• Humans
• Injections, Intralesional
• Keloid (drug therapy)
• Male
• Middle Aged
• Treatment Outcome