No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET.

Abstract

To investigate putative abnormalities of cortical 5-HT2A receptor density in schizophrenia, we used positron emission tomography and [18F]setoperone, a high-affinity 5-HT2A receptor radioligand, in 14 neuroleptic-free or -naive schizophrenic patients and in 15 normal controls. No significant difference between the groups was observed in the whole or regional cortical binding potential of [18F]setoperone, indicating an absence of major 5-HT2A receptor cortical density abnormalities in schizophrenics.

• Authors: C Trichard, M L Paillère-Martinot, D Attar-Levy, J Blin, A Feline, J L Martinot
• Journal: Schizophrenia research (Schizophr Res) Vol. 31 Issue 1 Pg. 13-7 (May 04 1998) ISSN: 0920-9964 [Print] Netherlands
• PMID: 9633832 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Pyrimidinones
• Receptors, Serotonin
• setoperone

Topics

• Adult
• Cell Count
• Cerebral Cortex (diagnostic imaging, metabolism)
• Female
• Functional Laterality
• Humans
• Male
• Pyrimidinones (pharmacokinetics)
• Receptors, Serotonin (metabolism)
• Schizophrenia (diagnostic imaging, metabolism)
• Tomography, Emission-Computed