A high dose chemoradiotherapy and peripheral blood stem cell support combined with the CD34(+)-selection method in cyclin D1(+)-mantle cell lymphoma.

Abstract

Mantle cell lymphoma (MCL) is currently regarded as one of the most incurable lymphomas, although reliable prognostic indicators are not yet to be defined. In a previous report, it was indicated that most of the patients with immunohistochemically cyclin D1(+)-MCL pursued the lethal clinical course within 7 years, not having achieved complete remission (CR). Recently, a high dose chemoradiotherapy was carried out, this was supported by peripheral blood stem cell transplantation (PBSCT) using the CD34(+)-selection method in a 48-year-old female patient with cyclin D1(+)-MCL. The tumor cells were detected in her peripheral blood despite four courses of combination chemotherapy using CHOP regimen. Soon after the pre-conditioning of total body irradiation (TBI) and high dose melphalan, she received the PBSCT of 1.8 x 10(6)/kg CD34+ cells and showed rapid hematological recovery without life-threatening complications. The patient achieved CR and was alive, without disease, 730 days after PBSCT. Thus, CD34+ selected PBSCT appears to provide further insight into the effective treatment and possible cure of this aggressive disease, i.e. cyclin D1(+)-MCL.

• Authors: K Uehira, Y Kagami, M Ogura, R Suzuki, K Miura, H Tachi, T Kurokawa, T Kinoshita, T Murate, S Nakamura, Y Morishima
• Journal: International journal of hematology (Int J Hematol) Vol. 67 Issue 2 Pg. 187-90 (Feb 1998) ISSN: 0925-5710 [Print] Japan
• PMID: 9631586 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, CD34
• Cyclin D1
• Granulocyte Colony-Stimulating Factor
• Melphalan

Topics

• Antigens, CD34 (analysis)
• Combined Modality Therapy
• Cyclin D1 (analysis)
• Female
• Granulocyte Colony-Stimulating Factor (therapeutic use)
• Hematopoietic Stem Cell Mobilization (methods)
• Hematopoietic Stem Cell Transplantation (methods)
• Hematopoietic Stem Cells (immunology)
• Humans
• Lymphoma, Non-Hodgkin (chemistry, radiotherapy, therapy)
• Melphalan (administration & dosage, therapeutic use)
• Middle Aged