Neurogenic oedema and vasodilatation: effect of a selective neuronal NO inhibitor.

Abstract

The effects of a neuronal nitric oxide synthase (nNOS) inhibitor, 1-(2-trifluoromethylphenyl)imidazole (TRIM) on rat sensory saphenous nerve-induced neurogenic inflammation were investigated. TRIM (50 mg kg-1, i.p.), but not 2-trifluoromethylphenol (TRIMPOH) which lacks nNOS inhibitory activity, inhibited neurogenic oedema by 55.8 +/- 6.5% (n = 6, p < 0.05). The effect of TRIM was partially reversed by L-arginine (100 mg kg-1, i.v., p < 0.01). TRIM also caused a reduction (p < 0.05) in neurogenic vasodilatation but had no effect on neuropeptide responses induced by substance P + CGRP. Topically applied TRIM (100 microliters of 150-250 mg ml-1) inhibited neurogenic oedema (p < 0.01). Thus, use of this recently described nNOS inhibitor has provided new evidence to further the hypothesis that nNOS plays a role in modulating sensory nerve-mediated neurogenic inflammation.

• Authors: P K Towler, G S Bennett, P K Moore, S D Brain
• Journal: Neuroreport (Neuroreport) Vol. 9 Issue 7 Pg. 1513-8 (May 11 1998) ISSN: 0959-4965 [Print] England
• PMID: 9631458 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-trifluoromethylphenol
• Enzyme Inhibitors
• Hydrocarbons, Fluorinated
• Imidazoles
• Phenols
• Vasoconstrictor Agents
• 1-(2-trifluoromethylphenyl)imidazole
• Arginine
• Nitric Oxide Synthase
• Nitric Oxide Synthase Type I
• Nos1 protein, rat

Topics

• Animals
• Arginine (pharmacology)
• Edema (drug therapy, physiopathology)
• Electric Stimulation
• Enzyme Inhibitors (pharmacology)
• Hindlimb
• Hydrocarbons, Fluorinated (pharmacology)
• Imidazoles (pharmacology)
• Inflammation (drug therapy, physiopathology)
• Male
• Nitric Oxide Synthase (antagonists & inhibitors)
• Nitric Oxide Synthase Type I
• Peripheral Nerves (drug effects, physiology, physiopathology)
• Phenols (pharmacology)
• Rats
• Rats, Wistar
• Vasoconstrictor Agents (pharmacology)
• Vasodilation (drug effects)