Sustained improvement in blood lipids, coagulation, and fibrinolysis after major weight loss in obese subjects.

Abstract

OBJECTIVE:

To study whether major weight loss causes sustained improvement in blood lipids and haemostatic profile in obese subjects, and to compare the influence of two different slimming and maintenance regimens.

DESIGN:

Two-stranded randomized intervention study.

SETTING:

University Department.

SUBJECTS:

Thirty-six out of 43 obese patients recruited from out-patient waiting list completed the study.

INTERVENTIONS:

Weight loss was achieved by very low energy formula diet (2 MJ/d for 8 weeks, n=18), or low-energy conventional diet (5 MJ/d for 17 weeks, n=18), both combined with anorectic compound. Participants were re-randomized to consume low fat diet ad libitum (n=16), or energy-restricted diet (n=20) for weight maintenance during 24 weeks.

MAIN OUTCOME MEASURES:

Plasma lipids, fibrinogen, factor VII coagulant activity (FVIIc), and plasminogen activator inhibitor type 1 (PAI-1) antigen.

RESULTS:

Weight loss averaged 13.6 kg (95% CI: 12.3-14.9 kg). After 24 weeks' weight maintenance, plasma total cholesterol was 9% lower, high density lipoprotein cholesterol 5% higher, triglycerides 30% lower, FVIIc 12% lower, fibrinogen 6% lower, and PAI-1 antigen 34% lower than at baseline (all changes highly significant). There were no significant differences between slimming or maintenance regimens.

CONCLUSIONS:

Major weight loss is associated with sustained and marked improvements in blood lipids and hemostatic profile, irrespective of the tested slimming and maintenance regimens.

• Authors: P Marckmann, S Toubro, A Astrup
• Journal: European journal of clinical nutrition (Eur J Clin Nutr) Vol. 52 Issue 5 Pg. 329-33 (May 1998) ISSN: 0954-3007 [Print] England
• PMID: 9630382 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, HDL
• Lipids
• Plasminogen Activator Inhibitor 1
• Triglycerides
• Factor VII
• Fibrinogen
• Cholesterol

Topics

• Adult
• Blood Coagulation
• Body Mass Index
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Factor VII (metabolism)
• Female
• Fibrinogen (metabolism)
• Fibrinolysis
• Humans
• Lipids (blood)
• Male
• Middle Aged
• Obesity (diet therapy)
• Plasminogen Activator Inhibitor 1 (metabolism)
• Triglycerides (blood)
• Weight Loss