Efficacy of L-846 in patients with insomnia: evaluation by polysomnography.

Abstract

The effects of L-846, an ultra-short-acting pyrazolopyrimidine hypnotic, on sleep were studied in nine insomniacs and two neurotic patients with insomnia. The patients were randomly assigned to receive 5 mg (n=6) or 10 mg (n=5) L-846. The study schedule comprised of one adaptation night, two baseline nights, three drug nights, and two withdrawal nights. Sleep latency and slow wave sleep (SWS) latency was largely shortened and %SWS increased in the early phase of sleep. No clear evidence of rebound insomnia was noted.

• Authors: T Sakamoto, N Uchimura, M Mukai, H Mizuma, S I Shirakawa, Y Nakazawa
• Journal: Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 52 Issue 2 Pg. 156-7 (Apr 1998) ISSN: 1323-1316 [Print] Australia
• PMID: 9628124 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Acetamides
• Hypnotics and Sedatives
• Pyrimidines
• zaleplon

Topics

• Acetamides (therapeutic use)
• Adult
• Aged
• Dose-Response Relationship, Drug
• Female
• Humans
• Hypnotics and Sedatives (therapeutic use)
• Male
• Middle Aged
• Polysomnography
• Pyrimidines (therapeutic use)
• Sleep Initiation and Maintenance Disorders (drug therapy)
• Sleep Stages (drug effects)
• Treatment Outcome