Intralymphocyte free magnesium and plasma triglycerides.

Abstract

To evaluate the relative effect of hypertension and plasma triglycerides on intralymphocyte magnesium we measured ionized intralymphocyte magnesium (Mg(i)) concentration by means of a fluorimetric method based on the dye Furaptra in 4 groups of subjects: 18 normotensive normotriglyceridemic controls (NTNC), 9 hypertriglyceridemic normotensive patients (HTN), 8 hypertriglyceridemic essential hypertensive patients (HTEH), 17 normotriglyceridemic essential hypertensive patients (NTEH). Hypercholesterolemic, diabetic patients and alcoholics were excluded from the study. Mg(i) was found to be statistically reduced (ANOVA test F=10.41, P=0.0001) in both HTN and HTEH (M+/- SD, HTN: 0.235 +/- 0.01, HTEH: 0.236 +/- 0.01 mmol/l) as compared to both NTNC and NTEH (M +/- SD, NTNC: 0.294 +/- 0.008, NTEH: 0.297 +/- 0.009 mmol/l). A statistically significant negative correlation was found in the population as a whole between Mg(i) and plasma triglycerides (n=52, R= -541, P=0.00004). Our data suggest that hypertriglyceridemia per se and possibly the so-called plurimetabolic syndrome is characterized by low intralymphocyte free magnesium.

• Authors: P Delva, C Pastori, M Degan, G Montesi, A Lechi
• Journal: Life sciences (Life Sci) Vol. 62 Issue 24 Pg. 2231-40 ( 1998) ISSN: 0024-3205 [Print] Netherlands
• PMID: 9627082 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Triglycerides
• Magnesium

Topics

• Adult
• Blood Pressure (physiology)
• Female
• Humans
• Hypertension (metabolism)
• Hypertriglyceridemia (metabolism)
• Lymphocytes (metabolism)
• Magnesium (metabolism)
• Male
• Middle Aged
• Spectrometry, Fluorescence
• Triglycerides (blood)