Abstract |
The tolerance and the efficacy of the paclitaxel- vinorelbine- cisplatin combination ( PVC regimen) was evaluated in 33 patients with anthracycline-resistant stage IV breast cancer, who had disease progression under anthracycline- or mitoxantrone-based chemotherapy. Fourteen (42%) and 19 (58%) patients had primary and secondary resistance to anthracyclines, respectively; 70% had visceral metastases. Patients received vinorelbine (25 mg/m2) followed by paclitaxel (135 mg/m2) in a 3-hour infusion on day 1, and cisplatin (CDDP; 80 mg/m2) on day 2, in a 3-week schedule. A total of 208 chemotherapy courses were administered (median six courses per patient). Grade 3/4 neutropenia occurred in 13 patients (39%), seven of whom were hospitalized for neutropenic fever (5% of the courses). There was no toxic death. Grade 4 thrombocytopenia occurred in two patients (6%) and grade 3 anemia in three patients (9%). Grade 2 and 3 neurosensory toxicity occurred in 11 patients (32%) and two patients (6%), respectively, and grade 3/4 fatigue was observed in four patients (12%). Two (6%) complete and 17 partial responses (52%) (total, 58%; 95% confidence interval, 42%-75%) were documented. Stable disease was observed in eight patients (24%) and progression in six patients (18%). The median duration of response was 6.5+ months. The median survival was 15+ months, and the 1-year survival was 67%. In conclusion, PVC regimen is an active and well-tolerated salvage chemotherapy in patients resistant to anthracycline.
|
Authors | C Kourousis, S Kakolyris, N Androulakis, P Heras, J Vlachonicolis, L Vamvakas, M Vlata, D Hatzidaki, G Samonis, V Georgoulias |
Journal | American journal of clinical oncology
(Am J Clin Oncol)
Vol. 21
Issue 3
Pg. 226-32
(Jun 1998)
ISSN: 0277-3732 [Print] United States |
PMID | 9626786
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antibiotics, Antineoplastic
- Taxoids
- Vinblastine
- Paclitaxel
- Cisplatin
|
Topics |
- Adult
- Aged
- Antibiotics, Antineoplastic
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Breast Neoplasms
(drug therapy, mortality, pathology)
- Cisplatin
(adverse effects, therapeutic use)
- Drug Resistance, Neoplasm
- Female
- Humans
- Middle Aged
- Neoplasm Metastasis
- Paclitaxel
(adverse effects, therapeutic use)
- Patient Compliance
- Salvage Therapy
(adverse effects)
- Survival Analysis
- Taxoids
- Vinblastine
(adverse effects, analogs & derivatives, therapeutic use)
|