[Morphologic findings in liver tissue in mice after long-term administration of the herbicide fomesafan].

Abstract

Administration of herbicide fomesafen and of fomesafen combined with one dose of iron to 44 mice during 3 to 14 months caused hyperplastic and preneoplastic changes in the liver tissue which had been described in experimental carcinogenesis* small groups of altered hepatocytes storing glycogen or lipids and foci of small basophilic liver cells occurred as early as after 3 months. Altered hepatocytes were found more frequently in mice getting fomesafen and iron. Later nodular hyperplasia of liver cells developed with nodes 3-20 mm in diameter which mostly consisted of altered hepatocytes with plenty of glycogen. After 12 and 14 month-lasting administration of fomesafen and fomesafen with iron, the hepatocellular carcinoma was proved in 5 mice. In 4 mice, the preneoplastic changes in liver tissue were accompanied by micronodular hyperplasia of liver cells which did not participate on the development of big nodes and hepatocellular carcinoma.

• Authors: A Chlumská, F Fakan, J Krijt
• Journal: Ceskoslovenska patologie (Cesk Patol) Vol. 34 Issue 2 Pg. 67-71 (Apr 1998) ISSN: 1210-7875 [Print] Czech Republic
• Vernacular Title: Morfologické nálezy v jaterní tkáni mysí po dlouhodobém podávání herbicidu fomesafenu.
• PMID: 9624829 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzamides
• Herbicides
• Iron
• fomesafen

Topics

• Animals
• Benzamides (toxicity)
• Herbicides (toxicity)
• Iron (toxicity)
• Liver (drug effects, pathology)
• Liver Neoplasms, Experimental (chemically induced, pathology)
• Male
• Mice
• Mice, Inbred ICR