Abstract | BACKGROUND: The successful treatment of bacterial prostatitis depends on an effective antimicrobial concentration in prostatic tissue against the infecting organism. In this study we compared the diffusion of 5 types of antimicrobials into the prostate. METHODS: RESULTS: Although amikacin showed the highest mean concentration both in prostatic tissue and prostatic fluid, the prostatic tissue/serum ratio was significantly higher (P < 0.01) for ofloxacin (1.49 +/- 0.80) and minocycline (0.94 +/- 0.39) compared with those for amikacin (0.49 +/- 0.21) and piperacillin (0.21 +/- 0.15). Also, the prostatic fluid/serum ratio was lower than the prostatic tissue/serum ratio for each drug, however, the prostatic fluid/serum ratio of ofloxacin was significantly higher than that of other antimicrobials tested (P < 0.01). CONCLUSION:
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Authors | T Goto, S Makinose, Y Ohi, D Yamauchi, T Kayajima, K Nagayama, H Hayami |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 5
Issue 3
Pg. 243-6
(May 1998)
ISSN: 0919-8172 [Print] Australia |
PMID | 9624555
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(blood, pharmacokinetics)
- Body Fluids
(metabolism)
- Diffusion
- Humans
- Hydrogen-Ion Concentration
- Male
- Middle Aged
- Osmolar Concentration
- Prostate
(metabolism)
- Prostatic Hyperplasia
(metabolism)
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