Anti-inflammatory effect of hamamelis lotion in a UVB erythema test.

Abstract

BACKGROUND:

Although Hamamelis virginiana has long been used in the traditional treatment of skin diseases, there are few controlled clinical studies defining the extent of its anti-inflammatory action.

OBJECTIVE:

The anti-inflammatory efficacy of pH5 Eucerin aftersun lotion with 10% hamamelis distillate, the vehicle and a prior aftersun formulation were tested in 30 healthy volunteers using a modified UVB erythema test as model of inflammation.

METHODS:

Four UVB doses ranging from 1 to 2 MED were evaluated in each subject. Test fields on the back were treated occlusively for 48 h following irradiation. Chromametry and visual scoring were used to determine the degree of erythema in the treated fields and an untreated, irradiated control field 7, 24 and 48 h after irradiation.

RESULTS:

Erythema suppression ranged from approximately 20% of 7 h to 27% at 48 h in the hamamelis fields. A suppression of 11-15% was recorded in the fields treated with the other lotions. Significant differences were noted between hamamelis and these lotions.

CONCLUSION:

These data provide evidence for an anti-inflammatory action of the aftersun lotion with 10% hamamelis and support the usefulness of the UVB erythema test with multiple UV doses for the testing of nonsteroidal anti-inflammatory agents.

• Authors: B J Hughes-Formella, K Bohnsack, F Rippke, G Benner, M Rudolph, I Tausch, J Gassmueller
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 196 Issue 3 Pg. 316-22 ( 1998) ISSN: 1018-8665 [Print] Switzerland
• PMID: 9621139 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Lipids
• Ointment Bases
• Plant Extracts
• eucerin

Topics

• Adult
• Erythema (drug therapy, etiology)
• Female
• Humans
• Lipids
• Male
• Middle Aged
• Ointment Bases (therapeutic use)
• Plant Extracts (therapeutic use)
• Reference Values
• Treatment Outcome
• Ultraviolet Rays (adverse effects)