Mebendazole in treatment of severe Trichuris trichiura infection in Malaysian children.

Abstract

Children with severe Trichuris trichiura infection pose significant social, clinical, and therapeutic problems in Malaysia. Thirty such children were investigated, and mebendazole was found to be safe and effective in the treatment of severe trichuriasis but it had to be given for a longer period than currently recommended. A poor correlation was found between egg load and worm burden in these children. Direct visualization of the rectal and colonic mucosa was the most reliable method of assessing severity in untreated cases, and response to treatment. The eggs of Trichuris that had been exposed to mebendazole were morphologically altered and not viable when incubated. This may be of considerable epidemiological importance.

• Authors: I Nagalingam, L E Lam, M J Robinson, A S Dissanaike
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 25 Issue 4 Pg. 568-72 (Jul 1976) ISSN: 0002-9637 [Print] United States
• PMID: 961974 (Publication Type: Journal Article)

Chemical References

• Benzimidazoles
• Mebendazole

Topics

• Adolescent
• Benzimidazoles (therapeutic use)
• Child
• Child, Preschool
• Feces (parasitology)
• Female
• Humans
• In Vitro Techniques
• Malaysia
• Male
• Mebendazole (therapeutic use)
• Trichuriasis (drug therapy, parasitology)