Mode of action of torilin in multidrug-resistant cancer cell lines.

Abstract

The mechanism of action of multidrug-resistance reversing activity of torilin was studied. In vitro experiments for the accumulation and efflux of vinblastine clearly indicated that MDR reversing effects of torilin would directly be associated with the increase of the intracellular accumulation of anticancer drugs by blocking the drug efflux. Furthermore, torilin increased the membrane ATPase activity from KB-V1 cells, suggesting that torilin might function by inhibiting drug transport mediated by P-glycoprotein.

• Authors: S E Kim, Y S Hong, Y C Kim, J J Lee
• Journal: Planta medica (Planta Med) Vol. 64 Issue 4 Pg. 335-8 (May 1998) ISSN: 0032-0943 [Print] Germany
• PMID: 9619116 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Antineoplastic Agents, Phytogenic
• Sesquiterpenes
• Sesquiterpenes, Guaiane
• Vinblastine
• Verapamil
• Adenosine Triphosphatases
• torilin

Topics

• ATP Binding Cassette Transporter, Subfamily B, Member 1 (metabolism)
• Adenosine Triphosphatases (metabolism)
• Antineoplastic Agents, Phytogenic (metabolism, pharmacology)
• Biological Transport
• Cell Membrane (enzymology)
• Drug Resistance, Multiple
• Drug Resistance, Neoplasm
• Drug Synergism
• Humans
• Sesquiterpenes (pharmacology)
• Sesquiterpenes, Guaiane
• Tumor Cells, Cultured
• Verapamil (metabolism, pharmacology)
• Vinblastine (metabolism, pharmacology)