HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cerebral and cerebellar activation in correlation to the action-induced dystonia in writer's cramp.

Abstract
The pattern of brain perfusion of four patients with writer's cramp and four control subjects were examined using positron emission tomography scans after [(15)O] butanol injections. Each subject was scanned 12 times to cover three repetitions of four different motor tasks with the right hand. Drawing of horizontal lines and variable durations of the writing of a prelearned text were performed in a pseudorandom order, the latter task commencing either simultaneously with or 30 sec or 120 sec before the tracer injection. The perceived difficulty and signs of dystonia progressed in correlation to the duration of writing. Statistical parametric maps were calculated to test hypotheses of regional specific effects dependent on the performed motor tasks. The patients with writer's cramp had progressively increased activity in the left primary sensorimotor and premotor cortices, the left thalamus, and the cerebellum with a right-side predominance in correlation to the duration of writing. The regions with activity increases thus corresponded to a cerebrocerebellar motor circuit. The duration of writing correlated to a progressive reduction of activity in the patients' left supramarginal and angular gyri (Brodmann areas 40 and 39) and an inferior part of the left temporal lobe (area 20). The control subjects had neither a significant increase or decrease of activity in correlation to the duration of writing. Group-specific differences were confirmed statistically in split-plot interaction analyses.
AuthorsT Odergren, S Stone-Elander, M Ingvar
JournalMovement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 13 Issue 3 Pg. 497-508 (May 1998) ISSN: 0885-3185 [Print] United States
PMID9613744 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adult
  • Brain (blood supply, diagnostic imaging, physiopathology)
  • Cerebellum (blood supply, diagnostic imaging, physiopathology)
  • Female
  • Functional Laterality (physiology)
  • Handwriting
  • Humans
  • Male
  • Middle Aged
  • Motor Cortex (blood supply, diagnostic imaging, physiopathology)
  • Motor Neurons (physiology)
  • Muscle Cramp (diagnostic imaging, physiopathology)
  • Oxygen Consumption (physiology)
  • Regional Blood Flow (physiology)
  • Somatosensory Cortex (blood supply, diagnostic imaging, physiopathology)
  • Tomography, Emission-Computed

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: