[Effect of kyotorphin on the seizure activity induced by kainic acid during picrotoxin kindling in rats].

Abstract

In Wistar rats, the ED-50 of kainic acid induced clonic seizures. In early and postponed periods of kindling, the ED-50 decreased by 2,0 to 1.5 times. Kyotorphin did not affect the ED-50 of kainic acid in postponed periods.

• Authors: A I Brusentsov
• Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova (Ross Fiziol Zh Im I M Sechenova) 1998 Jan-Feb Vol. 84 Issue 1-2 Pg. 115-8 ISSN: 0869-8139 [Print] Russia (Federation)
• Vernacular Title: Vliianie kiotorfina na sudorozhnuiu aktivnost', vyzvannuiu kainovoĭ kislotoĭ pri pikrotoksinovom kindlinge u krys.
• PMID: 9612866 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anticonvulsants
• Convulsants
• Endorphins
• Excitatory Amino Acid Agonists
• kyotorphin
• Picrotoxin
• Kainic Acid

Topics

• Animals
• Anticonvulsants (pharmacology)
• Convulsants (toxicity)
• Endorphins (pharmacology)
• Excitatory Amino Acid Agonists (metabolism, toxicity)
• Kainic Acid (metabolism, toxicity)
• Kindling, Neurologic
• Male
• Picrotoxin (toxicity)
• Rats
• Rats, Wistar
• Seizures (chemically induced, physiopathology)