Abstract | BACKGROUND: METHODS: Between April 1989 and December 1993, 211 previously untreated patients with intermediate grade and high grade non-Hodgkin's lymphoma were randomized to receive either doxorubicin (n=106) or epirubicin (n=105) with the MACOP-B regimen. These patients were followed through December 1996. Numerous clinical features predictive of response and survival were analyzed. Cardiac and noncardiac toxicity in the two treatment arms were compared. RESULTS: The median age of the patients was 48 years. Complete remission was experienced by 122 patients (58.3%); 62 patients (58.5%) achieved complete remission in the doxorubicin arm and 60 (58.1%) in the epirubicin arm. Response rates, time to treatment failure, relapse data, and overall survival were comparable between the two arms. Morbidity due to mucositis, vomiting, peripheral neuropathy, and cardiotoxicity were also comparable. The overall mortality was 10%. Mortality due to neutropenic sepsis was considerably higher among patients who received epirubicin (10 patients) than among those who received doxorubicin (5 patients). Cardiac evaluation revealed no difference in toxicity between the two arms. CONCLUSIONS:
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Authors | R Nair, G Ramakrishnan, N N Nair, T K Saikia, P M Parikh, S R Joshi, C S Soman, M Mukhadan, K T Dinshaw, S H Advani |
Journal | Cancer
(Cancer)
Vol. 82
Issue 11
Pg. 2282-8
(Jun 01 1998)
ISSN: 0008-543X [Print] United States |
PMID | 9610711
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antibiotics, Antineoplastic
- Epirubicin
- Doxorubicin
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Topics |
- Adolescent
- Adult
- Aged
- Antibiotics, Antineoplastic
(therapeutic use)
- Doxorubicin
(adverse effects, therapeutic use)
- Epirubicin
(adverse effects, therapeutic use)
- Female
- Humans
- Lymphoma, Non-Hodgkin
(drug therapy, mortality)
- Male
- Middle Aged
- Recurrence
- Survival Rate
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