Effect of human alpha2-macroglobulin on proliferative activity of rat tumor cells.

Abstract

The Walker carcinosarcoma cells were cultured in the medium with low concentration (0.25%) of fetal calf serum, in the presence of native or methylamine-treated (modified) human alpha 2-macroglobulin (alpha 2-MG) in vitro. The proliferative activity (3H-thymidine incorporation) of these cells increased in the presence of one or the other alpha 2-MG preparation. It allows to suppose that the human alpha 2-MG may serve as a growth-stimulating factor of tumour cells.

• Authors: N V Mal'tseva, S V Arkhipova, N A Zorin
• Journal: Tsitologiia (Tsitologiia) Vol. 40 Issue 2-3 Pg. 167-71 ( 1998) ISSN: 0041-3771 [Print] Russia (Federation)
• Vernacular Title: Vliianie alpha2-makroglobulina cheloveka na proliferativnuiu opukholevykh kletok krys]
• PMID: 9610481 (Publication Type: English Abstract, Journal Article)

Chemical References

• Methylamines
• alpha-Macroglobulins
• methylamine

Topics

• Animals
• Carcinosarcoma (pathology)
• Cell Division (drug effects)
• Humans
• Methylamines (chemistry)
• Rats
• Tumor Cells, Cultured
• alpha-Macroglobulins (chemistry, pharmacology)