HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Evaluation of antimicrobial efficacy and release pattern of tetracycline and metronidazole using a local delivery system.

Abstract
The present study compared the effectiveness of two antimicrobials, tetracycline and metronidazole, in reducing subgingival microorganisms in periodontal pockets using an ethyl cellulose strip as the delivery medium. The study involved 30 patients, with a minimum of 3 periodontal pockets with probing depths > 6 mm throughout the oral cavity. Patients were given supragingival scaling and then divided into 5 groups, depending on the length of time the medication was in place. Sites were marked for tetracycline, metronidazole, and placebo. Sites were wiped and isolated, and baseline microbiology samples were taken for Gram staining and culture methods. After treatment, subgingival microbiological samples were taken again. The ethyl cellulose strips were removed and analyzed for any remaining drug. Results showed that tetracycline and metronidazole can both be applied locally to periodontal sites using ethyl cellulose strips and markedly suppress the subgingival bacteria over a period of several days. The tetracycline showed a faster release; however, the metronidazole required a lesser concentration to achieve complete reduction of the subgingival flora.
AuthorsB V Somayaji, U Jariwala, P Jayachandran, K Vidyalakshmi, R V Dudhani
JournalJournal of periodontology (J Periodontol) Vol. 69 Issue 4 Pg. 409-13 (Apr 1998) ISSN: 0022-3492 [Print] United States
PMID9609369 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Anti-Infective Agents, Local
  • Antitrichomonal Agents
  • Metronidazole
  • ethyl cellulose
  • Cellulose
  • Tetracycline
Topics
  • Adult
  • Anti-Bacterial Agents (administration & dosage)
  • Anti-Infective Agents, Local (therapeutic use)
  • Antitrichomonal Agents (administration & dosage)
  • Cellulose (analogs & derivatives, chemistry)
  • Colony Count, Microbial
  • Dose-Response Relationship, Drug
  • Drug Delivery Systems
  • Female
  • Hardness
  • Humans
  • Male
  • Metronidazole (administration & dosage)
  • Microbial Sensitivity Tests
  • Middle Aged
  • Periodontal Pocket (drug therapy, microbiology)
  • Tetracycline (administration & dosage)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: