Effect of hexachloro-1,3-butadiene on renal carcinogenesis in male rats pretreated with N-ethyl-N-hydroxyethylnitrosamine.

Abstract

Hexachloro-1,3-butadiene (HCBD) is a potent nephrotoxicant that selectively damages the straight portion (pars recta) of the proximal tubule in the rat. To determine its effects on carcinogenesis. HCBD was administered for 30 wk at a concentration of 0.1% by weight in basal diet to male Wistar rats previously given 0.1% N-ethyl-N-hydroxyethylnitrosamine (EHEN) in the drinking water for 2 wk. The combined treatment resulted in a significantly higher incidence of renal cell tumors than when EHEN was administered alone. This chronic exposure and a short course of a 0.2% HCBD diet for 3 wk caused marked increase in the numbers of bromodeoxyuridine-incorporating cells or proliferating cell nuclear antigen-positive cells in the outer stripe of the kidney. The ability of HCBD to promote EHEN-initiated renal tumorigenesis in rats thus appears to be associated intimately with linked nephropathy and subsequent cell proliferation.

• Authors: Y Nakagawa, Y Kitahori, M Cho, N Konishi, K Tsumatani, S Ozono, E Okajima, Y Hirao, Y Hiasa
• Journal: Toxicologic pathology (Toxicol Pathol) 1998 May-Jun Vol. 26 Issue 3 Pg. 361-6 ISSN: 0192-6233 [Print] United States
• PMID: 9608641 (Publication Type: Journal Article)

Chemical References

• Butadienes
• Proliferating Cell Nuclear Antigen
• N-ethyl-N-hydroxyethylnitrosamine
• Diethylnitrosamine
• hexachlorobutadiene
• Bromodeoxyuridine

Topics

• Adenoma (chemically induced, chemistry, pathology)
• Animals
• Body Weight (drug effects)
• Bromodeoxyuridine
• Butadienes (administration & dosage, pharmacology)
• Cell Division
• Cocarcinogenesis
• Diethylnitrosamine (administration & dosage, analogs & derivatives)
• Drug Administration Schedule
• Hyperplasia (chemically induced, pathology)
• Kidney Neoplasms (chemically induced, chemistry, pathology)
• Kidney Tubules, Proximal (chemistry, drug effects, pathology)
• Male
• Organ Size (drug effects)
• Proliferating Cell Nuclear Antigen (analysis)
• Rats
• Rats, Wistar