HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

How platelet aggregation affects B16BL6 melanoma cell trafficking.

Abstract
In blood-borne metastasis, intravasated metastatic tumor cells are thought to localize at the target site via a series of processes involving platelet aggregation, adhesion to endothelium, and invasion through the basal membrane. In the present study, we examined how platelet aggregation contributes to the trafficking of metastatic tumor cells in vivo by use of an inhibitor of platelet aggregation. Highly invasive B16BL6 melanoma cells were labeled with [2-18F]2-fluoro-2-deoxy-D-glucose and injected into mice to determine cell trafficking non-invasively by positron emission tomography. Both platelet aggregation inhibitor cyclo(RSarDPhg), which could not inhibit metastasis, and metastatic inhibitor cyclo(GRGDSPA) suppressed the accumulation of B16BL6 cells in the lung by about 12%, suggesting that platelet aggregation partly affects cell trafficking but not to a great extent, and that platelet aggregation is not the essential step for B16BL6 cell arrest in targets.
AuthorsC Koike, M Watanabe, A Isoai, H Kumagai, H Tsukada, T Irimura, S Okada, N Oku
JournalFEBS letters (FEBS Lett) Vol. 427 Issue 2 Pg. 286-90 (May 08 1998) ISSN: 0014-5793 [Print] England
PMID9607330 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Peptides, Cyclic
  • Platelet Aggregation Inhibitors
  • cyclo(glycyl-arginyl-glycyl-aspartyl-seryl-aspartyl-alanyl)
Topics
  • Animals
  • Cell Adhesion
  • Lung Neoplasms (secondary)
  • Melanoma, Experimental (pathology, physiopathology, secondary)
  • Mice
  • Mice, Inbred C57BL
  • Neoplasm Metastasis (physiopathology)
  • Peptides, Cyclic (pharmacology)
  • Platelet Aggregation (physiology)
  • Platelet Aggregation Inhibitors (pharmacology)
  • Tomography, Emission-Computed
  • Tumor Cells, Cultured

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: