Abstract |
Norfloxacin 400 mg twice-a-day has proven to be effective and safe in the treatment of uncomplicated urinary tract infections (UTI). Since previous pharmacokinetic studies demonstrate the feasibility of using norfloxacin 800 mg once-daily, and this scheme is assumed to improve patient compliance, a double-blind randomized clinical trial was performed to compare the efficacy and safety of norfloxacin 800 mg once-daily (Group A) versus norfloxacin 400 mg twice-daily (Group B) in the treatment of adult female UTI for a 7-10 day period. Eighty-six adult women with clinical symptoms and urinary sediment signs suggestive of UTI were enrolled. In Group A, treatment was clinically assessed as effective in 95.3% and bacteriologically effective in 92.0% of the patients. In Group B, clinical and bacteriological efficacy was 100% and 95.5%, respectively. Differences between groups are not statistically significant. Adverse events were reported by 14.0% of patients in Group A and 9.6% in Group B (difference not statistically significant). There was one withdrawal due to dizziness. In this study, norfloxacin 800 mg once-a-day was as effective and safe as norfloxacin 400 mg twice-a-day in the treatment of uncomplicated urinary tract infections in women.
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Authors | F L Pimentel, A Dolgner, J Guimarães, M Quintas, J Mário-Reis |
Journal | Journal of chemotherapy (Florence, Italy)
(J Chemother)
Vol. 10
Issue 2
Pg. 122-7
(Apr 1998)
ISSN: 1120-009X [Print] England |
PMID | 9603637
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Infective Agents
- Norfloxacin
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Infective Agents
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Enterococcus
(drug effects)
- Escherichia coli
(drug effects)
- Female
- Humans
- Middle Aged
- Norfloxacin
(administration & dosage, therapeutic use)
- Proteus mirabilis
(drug effects)
- Staphylococcus
(drug effects)
- Treatment Outcome
- Urinary Tract Infections
(drug therapy, microbiology)
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