No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder.

Abstract

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in bipolar affective disorder I or unipolar major affective disorder was performed by using a Bfa I restriction site polymorphism within intron 7 of the tryptophan hydroxylase gene. A total of 118 bipolar, 125 unipolar, and 437 control subjects were used in the study (1:3.7 bipolar:control, 1:3.5 unipolar:control). There were no significant differences in TPH allele or genotype frequencies between the affective disorder and control groups. In addition, bipolar and/or unipolar subjects with or without a history of suicide attempts were compared for the TPH polymorphism. No significant differences were found between suicidal and non-suicidal groups in major affective disorder, in contrast to a previous study suggesting an association of this polymorphism with a history of suicide attempts among alcoholic violent offenders.

• Authors: R A Furlong, L Ho, J S Rubinsztein, C Walsh, E S Paykel, D C Rubinsztein
• Journal: American journal of medical genetics (Am J Med Genet) Vol. 81 Issue 3 Pg. 245-7 (May 08 1998) ISSN: 0148-7299 [Print] United States
• PMID: 9603613 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tryptophan Hydroxylase

Topics

• Bipolar Disorder (enzymology, genetics)
• Female
• Gene Frequency
• Humans
• Introns (genetics)
• Male
• Mood Disorders (enzymology, genetics)
• Polymorphism, Restriction Fragment Length
• Suicide, Attempted
• Tryptophan Hydroxylase (genetics)