[Effect of hypoxia on mitochondrial stability].

Abstract

The mitochondria isolated from the liver of rats subjected to acute hypoxia (10 km, 2h) are established to 0e less stable to the damage effect of incubation in the substratefree medium than the mitochondria of the control animals. A long interrupted adaptation to hypoxia as well as a single introduciton of p-chlorophenoxyacetic acid diethylaminoethylamide prevents a decrease in stability of the mitochondrial structures which is observed in rats during hypoxia. Addition of p-chlorophenoxyacetic acid diethylaminoethylamide into the incubation medium also inhibits the damage of the liver mitochondria.

• Authors: N Z Tamarina, A S Zakharevskiĭ
• Journal: Ukrains'kyi biokhimichnyi zhurnal (Ukr Biokhim Zh) 1976 Apr-Jun Vol. 48 Issue 3 Pg. 292-4 ISSN: 0041-610X [Print] Ukraine
• Vernacular Title: Vliianie gipoksii na ustoĭchivost' mitokhondriĭ
• PMID: 960236 (Publication Type: Journal Article)

Chemical References

• Sulfhydryl Compounds

Topics

• Acute Disease
• Adaptation, Physiological (drug effects)
• Animals
• Atmosphere Exposure Chambers
• Densitometry
• Hypoxia (metabolism)
• Male
• Mitochondria, Liver (analysis, drug effects, metabolism)
• Rats
• Sulfhydryl Compounds (analysis)
• Time Factors