Complications associated with transcatheter arterial embolization for hepatic tumors.

Abstract

Transcatheter arterial embolization (TAE) is widely used in the treatment of hepatic tumors. A total of 2,300 TAE procedures were performed with a 2-15-mL injection of a mixture or suspension of anticancer drugs and iodized oil, followed by administration of gelatin sponge particles. One or two chemotherapeutic drugs, including doxorubicin hydrochloride (10-30 mg), epirubicin hydrochloride (10-30 mg), mitomycin C (10-20 mg), and cisplatin (25-100 mg), were used for each procedure. Complications were encountered in 4.4% of cases (n = 102) and were related to the use of chemoembolic agents or the manipulation of a catheter or guide wire. These complications included acute hepatic failure (n = 6), liver infarction (n = 4) or abscess (n = 5), intrahepatic biloma (n = 20), multiple intrahepatic aneurysms (n = 6), cholecystitis (n = 7), splenic infarction (n = 2), gastrointestinal mucosal lesions (n = 5), pulmonary embolism or infarction (n = 4), tumor rupture (n = 1), variceal bleeding (n = 3), and iatrogenic dissection (n = 35) or perforation (n = 4) of the celiac artery and its branches. Knowledge of these complications is important for correct diagnosis and appropriate management.

• Authors: I Sakamoto, N Aso, K Nagaoki, Y Matsuoka, M Uetani, K Ashizawa, S Iwanaga, M Mori, M Morikawa, T Fukuda, K Hayashi, N Matsunaga
• Journal: Radiographics : a review publication of the Radiological Society of North America, Inc (Radiographics) Vol. 18 Issue 3 Pg. 605-19 ( 1998) ISSN: 0271-5333 [Print] United States
• PMID: 9599386 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Iodized Oil

Topics

• Angiography
• Antineoplastic Agents (administration & dosage, adverse effects)
• Carcinoma, Hepatocellular (therapy)
• Embolization, Therapeutic (adverse effects)
• Gelatin Sponge, Absorbable (administration & dosage, adverse effects)
• Hepatic Artery
• Humans
• Iodized Oil (administration & dosage, adverse effects)
• Liver Neoplasms (therapy)
• Tomography, X-Ray Computed