Susceptibility to idiopathic azoospermia in Japanese men is linked to HLA class I antigen.

Approximately 15 to 20% of infertile men have azoospermia. In the Y chromosome a deletion, termed the azoospermic factor, has been found in some cases of idiopathic azoospermia. We investigate the relationship of factors in autosomal chromosomes (HLA class I antigens) to spermatogenesis failure in idiopathic azoospermia.
We evaluated 65 infertile Japanese men with idiopathic azoospermia. The frequency of the HLA allele reported in 1,216 healthy Japanese men was used as a control. HLA class I typing was performed by the National Institutes of Health standard serological method or polymerase chain reaction-sequence specific primer analysis. Allele frequencies were calculated. We determined statistical significance in the frequency of each allele in patients and controls using the chi-square test. The relationship of HLA antigens to idiopathic azoospermia was expressed as relative risk.
In Japanese men with idiopathic azoospermia the frequency of HLA-A33, B13 and B44 was significantly increased compared with controls. The relative risk of HLA-B44 was 8.4, an extremely high value compared with that of other diseases and HLA antigens.
We suggest that HLA class I antigens are important genetic markers that represent a risk factor for idiopathic azoospermia.
AuthorsH Miura, A Tsujimura, K Nishimura, M Kitamura, N Kondoh, M Takeyama, H Fujioka, M Sada, T Tsuji, K Matsumiya, S Takahara, A Okuyama
JournalThe Journal of urology (J Urol) Vol. 159 Issue 6 Pg. 1939-41 (Jun 1998) ISSN: 0022-5347 [Print] UNITED STATES
PMID9598492 (Publication Type: Journal Article)
Chemical References
  • HLA-A Antigens
  • HLA-A*33 antigen
  • HLA-B Antigens
  • HLA-B44 Antigen
  • Histocompatibility Antigens Class I
  • Alleles
  • Disease Susceptibility
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-B44 Antigen
  • Histocompatibility Antigens Class I (genetics)
  • Humans
  • Japan
  • Male
  • Oligospermia (genetics, immunology)
  • Polymerase Chain Reaction
  • Risk Factors
  • Spermatogenesis (genetics, immunology)

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