HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

2-Methoxyisobutylisonitrile probe during parathyroid surgery: tool or gadget?

Abstract
The success of parathyroid surgery is determined by the identification and removal of all parathyroid tumors. Parathyroid tumors accumulate and retain 2-methoxyisobutylisonitrile (MIBI) labeled with technetium-99m. Intravenous injection of this radiopharmacon prior to parathyroid surgery allows identification of parathyroid tumors with a hand-held gamma detector. To assess the value of this technique, a case-control study was performed with 62 patient having nuclear-guided parathyroidectomy and 60 patients having conventional parathyroid explorations. The sensitivity rates of the MIBI probe in single and multiple gland disease were 84.6% and 63.0%, respectively. Rates of success, temporary and permanent hypoparathyroidism, and injury of the recurrent laryngeal nerve were similar in patients who underwent probe-guided surgery and those who had conventional surgery. In conclusion, although the MIBI probe appears to be a valuable tool in parathyroid surgery, its use has not improved the outcome of such surgery at our institution.
AuthorsH J Bonjer, H A Bruining, H A Pols, W W de Herder, C A Proye, B M Carnaille, R S Mohammedamin, E W Steyerberg, W A Breeman, E P Krenning
JournalWorld journal of surgery (World J Surg) Vol. 22 Issue 6 Pg. 507-11; discussion 511-2 (Jun 1998) ISSN: 0364-2313 [Print] United States
PMID9597920 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Technetium Tc 99m Sestamibi
Topics
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parathyroid Neoplasms (surgery)
  • Parathyroidectomy (methods)
  • Sensitivity and Specificity
  • Technetium Tc 99m Sestamibi

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: