Abstract |
The success of parathyroid surgery is determined by the identification and removal of all parathyroid tumors. Parathyroid tumors accumulate and retain 2-methoxyisobutylisonitrile (MIBI) labeled with technetium-99m. Intravenous injection of this radiopharmacon prior to parathyroid surgery allows identification of parathyroid tumors with a hand-held gamma detector. To assess the value of this technique, a case-control study was performed with 62 patient having nuclear-guided parathyroidectomy and 60 patients having conventional parathyroid explorations. The sensitivity rates of the MIBI probe in single and multiple gland disease were 84.6% and 63.0%, respectively. Rates of success, temporary and permanent hypoparathyroidism, and injury of the recurrent laryngeal nerve were similar in patients who underwent probe-guided surgery and those who had conventional surgery. In conclusion, although the MIBI probe appears to be a valuable tool in parathyroid surgery, its use has not improved the outcome of such surgery at our institution.
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Authors | H J Bonjer, H A Bruining, H A Pols, W W de Herder, C A Proye, B M Carnaille, R S Mohammedamin, E W Steyerberg, W A Breeman, E P Krenning |
Journal | World journal of surgery
(World J Surg)
Vol. 22
Issue 6
Pg. 507-11; discussion 511-2
(Jun 1998)
ISSN: 0364-2313 [Print] United States |
PMID | 9597920
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Technetium Tc 99m Sestamibi
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Topics |
- Case-Control Studies
- Female
- Humans
- Male
- Middle Aged
- Parathyroid Neoplasms
(surgery)
- Parathyroidectomy
(methods)
- Sensitivity and Specificity
- Technetium Tc 99m Sestamibi
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