Inhibitory effects of TRK-530 on rat adjuvant arthritis.

Abstract

TRK-530 is a novel bisphosphonate derivative. We examined the anti-inflammatory effects of TRK-530 on adjuvant arthritis (AA) rats. When TRK-530 at a dose of 2.5 mg/kg was administered for 2 weeks to AA rats, it inhibited destructive changes in arthritic joints such as paw edema, bone loss and joint degeneration. TRK-530 also inhibited splenomegaly and suppressed the increase in serum sialic acid which is measured as a systemic parameter of inflammation. To clarify the inhibitory mechanism of TRK-530, interleukin-1 (IL-1)-like activities of resident peritoneal macrophages in AA rats given TRK-530 were compared with those of control rats. We found that TRK-530 inhibited IL-1-like activity induced by bacterial lipopolysaccharide 6 weeks after administration when the IL-1-like activities of control rats were still at high levels. These findings suggest that TRK-530 exerts anti-inflammatory activities in AA rats.

• Authors: M Tanahashi, Y Funaba, M Itoh, N Kawabe, T Nakadate-Matsushita
• Journal: Pharmacology (Pharmacology) Vol. 56 Issue 5 Pg. 242-51 (May 1998) ISSN: 0031-7012 [Print] Switzerland
• PMID: 9597691 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Diphosphonates
• Interleukin-1
• TRK 530
• N-Acetylneuraminic Acid

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Arthritis, Experimental (drug therapy, pathology)
• Bone Marrow (pathology)
• Bone and Bones (pathology)
• Diphosphonates (therapeutic use)
• Female
• Foot (pathology)
• Hindlimb (pathology)
• Interleukin-1 (blood)
• Macrophages, Peritoneal (drug effects)
• N-Acetylneuraminic Acid (blood)
• Organ Size (drug effects)
• Rats
• Rats, Inbred Lew
• Spleen (pathology)