Successful thrombolysis of an occluded modified Blalock shunt three days after operation.

Abstract

A 10-day-old boy with pulmonary atresia received a right-sided aortopulmonary polytetrafluoroethylene shunt. Three days after the operation he became cyanotic and was reintubated. Shunt occlusion was confirmed with angiography. Recombinant tissue plasminogen activator was given locally into the proximal end of the shunt. The thrombus was completely resolved after 2 days. When administration of recombinant tissue plasminogen activator was stopped, heparin infusion was started for 5 days. Shunt patency was demonstrated by angiography at 3 months postoperatively.

• Authors: T K Malm, C Holmqvist, C G Olsson, J Johansson, A K Olsson, S Sandström, R Bennhagen, P Jögi
• Journal: The Annals of thoracic surgery (Ann Thorac Surg) Vol. 65 Issue 5 Pg. 1453-5 (May 1998) ISSN: 0003-4975 [Print] Netherlands
• PMID: 9594890 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticoagulants
• Polytetrafluoroethylene
• Heparin
• Plasminogen Activators
• Tissue Plasminogen Activator

Topics

• Anastomosis, Surgical (adverse effects)
• Angiography
• Anticoagulants (therapeutic use)
• Aorta (surgery)
• Blood Vessel Prosthesis (adverse effects)
• Blood Vessel Prosthesis Implantation (adverse effects)
• Cyanosis (etiology)
• Graft Occlusion, Vascular (diagnostic imaging, drug therapy)
• Heparin (therapeutic use)
• Humans
• Infant, Newborn
• Male
• Plasminogen Activators (therapeutic use)
• Polytetrafluoroethylene
• Pulmonary Artery (diagnostic imaging, surgery)
• Pulmonary Atresia (surgery)
• Thrombolytic Therapy
• Thrombosis (diagnostic imaging, drug therapy)
• Tissue Plasminogen Activator (therapeutic use)
• Vascular Patency