Abstract | OBJECTIVE: To measure serum 7S collagen (7S-C) and type VI collagen (VI-C) levels by radioimmunoassay (RIA) in Chinese patients with various liver disorders and in CCl4-treated SD rats, and to investigate the significance of the elevated levels of serum 7S-C and VI-C. METHODS: Serum 7S-C and VI-C levels were measured in 40 healthy control subjects, 168 patients with various liver disorders and non-hepatic diseases, and 52 CCl4-treated SD rats by using RIA which was developed in our hospital. RESULTS: CONCLUSIONS: Serum 7S collagen and type VI collagen are useful markers for diagnosing liver fibrosis. And the combined measurement of IV-C, VI-C and other markers of connective tissue metabolism or biochemical data seems to provide additional information to predict progressive hepatic fibrosis.
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Authors | X Ji, S Li, X Kong, G Xu, J Chen, X Dai |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 110
Issue 3
Pg. 198-201
(Mar 1997)
ISSN: 0366-6999 [Print] China |
PMID | 9594340
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Biomarkers
(blood)
- Carbon Tetrachloride Poisoning
- Carcinoma, Hepatocellular
(blood)
- Chemical and Drug Induced Liver Injury
(blood, etiology)
- Collagen
(blood)
- Hepatitis, Chronic
(blood)
- Humans
- Liver Cirrhosis
(blood, diagnosis)
- Liver Cirrhosis, Experimental
(blood, diagnosis)
- Liver Neoplasms
(blood)
- Male
- Rats
- Rats, Sprague-Dawley
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