HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Homologous and heterologous protection after single intranasal administration of live attenuated recombinant Bordetella pertussis.

Abstract
While single-dose mucosal immunization is best achieved by the use of attenuated live microorganisms, attenuation generally results in decreased immunogenicity. We attenuated Bordetella pertussis by the deletion of the pertussis toxin gene. A single intranasal administration of this strain protected against subsequent challenge as well as did the parent strain and better than immunization with commercial vaccine. Unexpectedly, this attenuation resulted in increased immunogenicity against the protective antigen filamentous hemagglutinin (FHA). In addition, immunogenicity was also enhanced against the Schistosoma mansoni Sm28GST genetically fused to FHA, resulting in protection against the parasite, as characterized by a reduction in worm burden and egg charge, after a single intranasal administration. Thus, attenuated recombinant B. pertussis strains are promising vectors for the simultaneous protection against pertussis and heterologous diseases by a single intranasal administration.
AuthorsN Mielcarek, G Riveau, F Remoué, R Antoine, A Capron, C Locht
JournalNature biotechnology (Nat Biotechnol) Vol. 16 Issue 5 Pg. 454-7 (May 1998) ISSN: 1087-0156 [Print] United States
PMID9592394 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adhesins, Bacterial
  • Antigens, Bacterial
  • Bacterial Vaccines
  • Hemagglutinins
  • Virulence Factors, Bordetella
  • filamentous hemagglutinin adhesin, Bordetella pertussis
  • Pertussis Toxin
Topics
  • Adhesins, Bacterial (genetics, pharmacology)
  • Administration, Intranasal
  • Animals
  • Antibody Formation (immunology)
  • Antigens, Bacterial (genetics, pharmacology)
  • Bacterial Vaccines (administration & dosage, immunology, pharmacology)
  • Bordetella pertussis (genetics, immunology)
  • Female
  • Hemagglutinins (genetics, pharmacology)
  • Mice
  • Pertussis Toxin
  • Schistosoma mansoni (drug effects, genetics)
  • Schistosomiasis mansoni (immunology, prevention & control)
  • Virulence Factors, Bordetella (immunology)
  • Whooping Cough (immunology, prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: