Carbamazepine-induced pseudolymphoma with CD-30 positive cells.

A 44-year-old woman known to be allergic to phenytoin was treated with carbamazepine for 1 month and developed fever, lymphadenopathy, pneumonitis, hepatitis, and a morbilliform eruption. A skin biopsy specimen showed atypical lymphocytes in the dermis that were CD-3+, CD-30+, and L26-. T-cell gene rearrangement studies were negative. A diagnosis of anticonvulsant hypersensitivity syndrome with histologic features of a pseudolymphoma was made and her illness quickly improved after carbamazepine was discontinued. This case was typical of the anticonvulsant hypersensitivity syndrome and demonstrated cross-reactivity among the aromatic anticonvulsants. However, to our knowledge, this represents the first report of a carbamazepine-induced hypersensitivity with histologic features of a cutaneous pseudolymphoma, including CD-30+ cells.
AuthorsD L Nathan, D V Belsito
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 38 Issue 5 Pt 2 Pg. 806-9 (May 1998) ISSN: 0190-9622 [Print] UNITED STATES
PMID9591791 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticonvulsants
  • Antigens, CD20
  • Antigens, CD3
  • Antigens, CD30
  • Carbamazepine
  • Adult
  • Anticonvulsants (adverse effects)
  • Antigens, CD20 (analysis)
  • Antigens, CD3 (analysis)
  • Antigens, CD30 (analysis)
  • Biopsy
  • Carbamazepine (adverse effects)
  • Cross Reactions
  • Drug Eruptions (etiology)
  • Drug Hypersensitivity (etiology)
  • Drug-Induced Liver Injury (etiology)
  • Female
  • Fever (chemically induced)
  • Gene Rearrangement, T-Lymphocyte
  • Humans
  • Lymphocytes (pathology)
  • Pneumonia (chemically induced)
  • Pseudolymphoma (chemically induced, pathology)
  • Skin Diseases (chemically induced, pathology)
  • Syndrome

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