For therapeutic and cosmetic modification of hair, we have developed a hair-follicle-selective macromolecule and small molecule targeting system with topical application of
phosphatidylcholine-based
liposomes.
Liposome-entrapped
melanins,
proteins, genes, and small-molecules have been selectively targeted to the hair follicle and hair shafts of mice. Liposomal delivery of these molecules is time dependent. Negligible amounts of delivered molecules enter the dermis, epidermis, or bloodstream thereby demonstrating selective follicle delivery. Naked molecules are trapped in the stratum corneum and are unable to enter the follicle. The potential of the hair-follicle
liposome delivery system for
therapeutic use for
hair disease as well as for cosmesis has been demonstrated in 3-dimensional histoculture of hair-growing skin and mouse in vivo models. Topical
liposome selective delivery to hair follicles has demonstrated the ability to color hair with
melanin, the delivery of the active lac-Z gene to hair matrix cells and delivery of
proteins as well.
Liposome-targeting of molecules to hair follicles has also been achieved in human scalp in histoculture.
Liposomes thus have high potential in selective hair follicle targeting of large and small molecules, including genes, opening the field of gene therapy and other molecular
therapy of the hair process to restore hair growth, physiologically restore or alter hair pigment, and to prevent or accelerate
hair loss.