A comparison of the therapeutic efficacy of conventional and modern oximes against supralethal doses of highly toxic organophosphates in mice.

Abstract	1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly more efficacious than conventional oximes but a little less efficacious than other H-oximes (HI-6, HLö-7). 3. H-oximes (HI-6, HLö-7) seem to be the most efficacious reactivators of nerve agent-inhibited acetylcholinesterase for antidotal treatment of supralethal nerve agent poisoning in mice.
Authors	J Kassa
Journal	Acta medica (Hradec Kralove) (Acta Medica (Hradec Kralove)) Vol. 41 Issue 1 Pg. 19-21 ( 1998) ISSN: 1211-4286 [Print] Czech Republic
PMID	9588068 (Publication Type: Comparative Study, Journal Article)
Chemical References	Chemical Warfare Agents Oximes
Topics	Animals Chemical Warfare Agents (poisoning) Lethal Dose 50 Male Mice Nervous System (drug effects) Organophosphate Poisoning Oximes (therapeutic use, toxicity)

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