The safety of pyrimethamine and sulfadoxine for the prevention of Pneumocystis carinii pneumonia.

Abstract	The medical records of 157 patients taking pyrimethamine-sulfadoxine for Pneumocystis carinii pneumonia prophylaxis were reviewed for assessment of safety and tolerance. 11 patients had experienced side effects, 7 (1 each: neutropenia, Stevens-Johnson, hepatic abnormalities; 2 each: subjective and hypersensitivity reactions) leading to a discontinuation of the drugs.
Authors	R Teira, M Virosta, J Muñoz, Z Zubero, J M Santamaría
Journal	Scandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 29 Issue 6 Pg. 595-6 ( 1997) ISSN: 0036-5548 [Print] England
PMID	9580544 (Publication Type: Journal Article)
Chemical References	Anti-Infective Agents Sulfadoxine Pyrimethamine
Topics	Adult Anti-Infective Agents (adverse effects, therapeutic use) Female Humans Incidence Male Pneumocystis (drug effects) Pneumonia, Pneumocystis (prevention & control) Pyrimethamine (adverse effects, therapeutic use) Retrospective Studies Stevens-Johnson Syndrome (chemically induced) Sulfadoxine (adverse effects, therapeutic use)

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