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Marked improvement of tardive dystonia after replacing haloperidol with risperidone in a schizophrenic patient.

Abstract
We report on a schizophrenic patient whose tardive dystonia, delusions, and auditory hallucinations showed remarkable concurrent improvement after replacing haloperidol with risperidone. The present finding suggests that the 5-hydroxytryptamine-2 (5-HT2) antagonistic action of risperidone has brought about the improvement in tardive dystonia. The 5-HT2 antagonistic action of risperidone, in addition to its dopamine antagonistic action, may have also lessened psychotic symptoms in the current case.
AuthorsK Yoshida, H Higuchi, Y Hishikawa
JournalClinical neuropharmacology (Clin Neuropharmacol) 1998 Jan-Feb Vol. 21 Issue 1 Pg. 68-9 ISSN: 0362-5664 [Print] United States
PMID9579290 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antipsychotic Agents
  • Serotonin Antagonists
  • Haloperidol
  • Risperidone
Topics
  • Antipsychotic Agents (adverse effects, therapeutic use)
  • Dystonia (chemically induced, physiopathology)
  • Haloperidol (adverse effects, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Risperidone (therapeutic use)
  • Schizophrenia (complications, drug therapy)
  • Schizophrenic Psychology
  • Serotonin Antagonists (therapeutic use)

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