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[Molluscum contagiosum in immunosuppression with methotrexate: multiple warts with central depressions of the eyelids].

AbstractBACKGROUND:
Poxvirus induced molluscum contagiosum is known to occur in children, elderly people and in patients with the acquired immune deficiency syndrome AIDS.
PATIENT AND METHODS:
We report on a 49-year-old patient who presented with a three-month history of multiple skin-coloured prominent warts on his right upper and lower eye-lid. On examination, the warts showed a central cavity and measured 2-6 mm in diameter. For his "mixed connective tissue disease" (MCTD) the patient took methotrexate in a weekly dosage of 7.5 mg since 3 years. Diagnosis of MCTD was made 7 years before. The warts were excised and studied histopathologically. One year postoperatively, there was no recurrence of the lesions.
CONCLUSION:
Drug induced immunosuppression as with methotrexate may be associated with multiple periocular lesions due to molluscum contagiosum.
AuthorsC Cursiefen, L M Holbach
JournalKlinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 212 Issue 2 Pg. 123-4 (Feb 1998) ISSN: 0023-2165 [Print] Germany
Vernacular TitleMolluscum contagiosum bei Immunsuppression mit Methotrexat: Multiple Dellwarzen der Lider.
PMID9577814 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Immunosuppressive Agents
  • Methotrexate
Topics
  • Biopsy
  • Diagnosis, Differential
  • Eyelid Diseases (chemically induced, pathology)
  • Eyelids (pathology)
  • Humans
  • Immunosuppressive Agents (adverse effects, therapeutic use)
  • Male
  • Methotrexate (adverse effects, therapeutic use)
  • Middle Aged
  • Mixed Connective Tissue Disease (drug therapy, pathology)
  • Molluscum Contagiosum (chemically induced, pathology)
  • Opportunistic Infections (chemically induced, pathology)

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